In the AI era, CIOs must simultaneously run and transform their businesses by partnering closely with HR and enterprise architects to adapt work processes and workforce skills. They need to identify which tasks will be automated or augmented by AI, redesign job roles accordingly, and ensure that systems support AI-augmented work while fostering key skills such as AI fluency, human judgment, and adaptability to remain competitive. This collaborative approach is vital for organizations to successfully navigate AI-driven disruptions and build future-ready enterprises.