Startups entering the North American market face unique cybersecurity compliance challenges, contrasting with the EU's GDPR framework. Key standards include ISO 27001, ISO 27701, and SOC 2, which help demonstrate trust and reduce risk. ISO certifications are compatible with SOC 2, and PCI DSS is mandatory for payment processing. HITRUST, initially for healthcare, is gaining traction across sectors. Compliance with US regulations like HIPAA and FedRAMP is essential in highly regulated industries. Startups should also prepare for future AI compliance with emerging standards like ISO 42001 as they expand into North America.