The article discusses how traditional enterprise operating models evolved into specialized, interconnected systems, with automation limited to structured, repetitive work. Generative and agentic AI represent a game-changing inflection point by handling complex, unstructured data, enabling businesses to redesign operating models and achieve faster, more adaptive workflows. Early adopters who integrate AI at the core gain long-lasting competitive advantages, while the CIO’s role is redefined from managing technology to leading organizational transformation around AI. The central question is whether CIOs will embrace this broader leadership mandate to orchestrate AI-native enterprises.